Menene peptides masu shiga tantanin halitta?

peptides masu shiga cikin tantanin halitta ƙananan peptides ne waɗanda ke iya shiga cikin tantanin halitta cikin sauƙi.Wannan nau'in kwayoyin halitta, musamman CPPs tare da ayyuka masu niyya, suna riƙe da alƙawarin ingantaccen isar da ƙwayoyi zuwa sel masu niyya.

Don haka, binciken da aka yi a kansa yana da wasu mahimmancin ilimin halitta.A cikin wannan binciken, an yi nazarin CPPs tare da ayyuka daban-daban na transmembrane a matakin jerin, ƙoƙarin gano abubuwan da ke shafar ayyukan CPPs, bambance-bambancen da ke tsakanin CPPs tare da ayyuka daban-daban da NonCPPs, da kuma gabatar da hanyar da za a yi nazarin tsarin nazarin halittu.

An samo jerin CPPs da NonCPPs daga bayanan CPPsite da wallafe-wallafe daban-daban, da kuma transmembrane peptides (HCPPs, MCPPs, LCPPs) tare da babban, matsakaici, da ƙananan ayyukan transmembrane daga jerin CPPs don gina bayanan bayanai.Bisa ga waɗannan bayanan, an gudanar da bincike kamar haka:

1, Amino acid da tsarin tsarin na biyu na CPPs masu aiki daban-daban da kuma waɗanda ba CPPs an yi nazarin su ta ANOVA.An gano cewa hulɗar electrostatic da hydrophobic na amino acid sun taka muhimmiyar rawa a cikin ayyukan transmembrane na CPPs, kuma tsarin helical da bazuwar coiling kuma ya shafi ayyukan CPPs na transmembrane.

2. Abubuwan da ke cikin jiki da sunadarai da tsayin CPPs tare da ayyuka daban-daban an nuna su a kan jirgin sama mai girma biyu.An gano cewa CPPs da NonCPPs masu ayyuka daban-daban za a iya tattara su a ƙarƙashin wasu kadarori na musamman, kuma an raba HCPPs, MCPPs, LCPPs da NonCPPs zuwa gungu uku, wanda ke nuna bambancinsu;

3. A cikin wannan takarda, an gabatar da manufar centroid ta zahiri da sinadari na jerin halittu, kuma ragowar da suka haɗa jeri ana ɗaukar su a matsayin maki, kuma an ƙazantar da jerin a matsayin tsarin barbashi don bincike.An yi amfani da wannan hanyar don nazarin CPPs ta hanyar ƙaddamar da CPPs tare da ayyuka daban-daban a kan jirgin 3D ta hanyar PCA, kuma an gano cewa yawancin CPPs sun taru tare da wasu LCPPs tare da NonCPPs.

Wannan binciken yana da tasiri ga ƙira na CPPs da fahimtar bambance-bambance a cikin jerin CPPs tare da ayyuka daban-daban.Bugu da kari, ana iya amfani da hanyar bincike na centroid ta jiki da sinadarai na jerin halittu da aka gabatar a cikin wannan takarda don nazarin wasu matsalolin halittu.A lokaci guda, ana iya amfani da su azaman sigogin shigarwa don wasu matsalolin rarrabuwar halittu kuma suna taka rawa wajen gane ƙira.