gabatarwa
Gorelatide, wanda kuma aka sani da n-acetyl-serine - aspartic acid - proline - proline -(N-Acetyl-Ser-Asp-Lys-Pro), wanda aka rage a matsayin Ac-SDKP, tetrapeptide ne na endogenous, ƙarshen acetylation na nitrogen, an rarraba shi sosai a ciki. daban-daban kyallen takarda da ruwan jiki a cikin jiki.Ana fitar da wannan tetrapeptide ta hanyar prolyl oligopeptidase (POP), wanda yawanci yakan haifar da thymosin precursor.Yawan taro a cikin jini yawanci akan ma'aunin nanomole ne.
okinetics
Dangane da binciken pharmacokinetic na Gorelatide, bayan allurar ta cikin jijiya, Gorelatide yana raguwa da sauri tare da rabin rayuwa na 4 ~ 5min kawai.Gorelatide an share shi daga plasma na mutum ta hanyoyi biyu:①Angiotensin-converting enzyme (ACE) - jagorancin hydrolysis;②Glomerular tacewa.Hydrolysis na angiotensin yana canza enzyme (ACE) shine babban hanyar metabolism na gorelatide.
Ayyukan halittu
Gorelatide wani nau'i ne na nau'in kayyade tsarin ilimin lissafi mai aiki da yawa tare da ayyukan ilimin halitta daban-daban.A baya an ba da rahoton cewa Gorelatide zai iya hana shigar da asalin asalin ƙwayoyin hematopoietic zuwa cikin lokaci na S kuma ya sanya su a tsaye a cikin lokacin G0, yana hana ayyukan sel na hematopoietic.Daga baya an gano cewa Gorelatide na iya haɓaka ƙarfin sake dasa epidermal ta hanyar haɓaka samuwar jijiya da kuma hanzarta warkar da rauni a cikin ɓarnawar ɓarna na jijiyoyi.Gorelatide na iya hana bambance-bambancen ƙwayar ƙwayar kasusuwa wanda MGM ya motsa zuwa cikin macrophages, don haka yana taka rawar anti-mai kumburi.An gano kwanan nan Gorelatide don hana yaduwar ƙwayoyin cuta iri-iri.
amfani
A matsayin kwayoyin halitta na polypeptide, ana iya amfani da Gorelatide azaman albarkatun ƙasa na magani.
Lokacin aikawa: Afrilu-26-2023