Sabuwar hanyar Thymus ta ƙunshi 28 amino acid synthetic polypeptide mai kula da rigakafi.Hanyar Thymus wani nau'i ne na sababbin magungunan uct, sau da yawa ana amfani dashi a cikin masu ciwon daji, na iya haɓaka rigakafi.
Hanyar aiki
Ba a yi cikakken nazari kan ainihin hanyar thymalfasin na maganin ciwon hanta ba, amma gwaje-gwaje daban-daban sun nuna cewa thymalfasin yana da tasiri mai mahimmanci na rigakafi.Ana samunsa ne ta hanyar inganta aikin ƙwayoyin T, kuma yana gudana ta cikin jihohin da suka haɗa da samar da kwayoyin T, rarrabawa da tsaftacewa, da apoptosis.Ta hanyar haɓaka cikakken adadin lymphoid, intrahepatic na halitta kisa, CD3 da CD4 Kwayoyin, thymalfasin na iya taka rawa immunomodulatory.Pleural fasin na iya inganta balaga da rarrabuwa na sel DC, don haka inganta balaga da rarraba ƙwayoyin T.Thymalfasin na iya kunna mitogen ko antigen, haɓaka samar da nau'ikan cytokines iri-iri irin su interferon ɗan adam interleukin IL2 da IL3, haɓaka maganganun mai karɓar interleukin-2, kuma ya sa ƙwayoyin CD4T su bambanta cikin THLS, waɗanda ke da tasirin antiviral.Ta hanyar haɓaka aikin sel P, yana iya haɓaka samar da ƙwayoyin lymphocytes a cikin vivo, daidaita ma'auni na sassan sel P da bambance-bambancen U, da kuma samar da ƙwayoyin cuta, tada samar da sauran ƙwayoyin cuta na ƙwayoyin cuta da macrophages, haɓaka haɗiye. aiki, da kuma inganta aikin tsarin rigakafi na salula a cikin marasa lafiya na ciwon daji.Hakanan yana iya cire ƙwayoyin cuta, ƙwayoyin cuta da ƙwayoyin cuta daga jiki.Littafin hanyar Thymus don tsarin juyayi da kewayen endothelium, tashi don daidaita aikin watsawar synaptic neuron hippocampal.Hanyar Thymus sabon watsawar synaptic mai ban sha'awa da tsarin jin tsoro, ana iya amfani da shi don hana marasa lafiya da ciwon daji da ke haifar da ciwon daji kamar chemotherapy da neurotoxicity.Pleuraxin yana da tasirin kayyade kwayoyin halitta, zai iya haifar da ƙwayoyin halittar kinase cascade, ƙara ƙwayoyin cytokine, ƙwayoyin amsawar rigakafi.Haɓaka ƙa'idodin thymalfasin akan IL-like receptor genes yana nuna cewa thymalfasin yana ƙarfafa sel masu gabatar da antigen."Bugu da ƙari, tasirin thymalfasin akan haɓakar ƙwayoyin rigakafi yana nunawa a cikin haɓakar abubuwan haɓakar ƙwayoyin ƙwayoyin cuta da ƙwayoyin furotin na hematopoietic."
Sabon jerin thymectomy
Tsarin shiri
1. Hanyar hakar kwayoyin halitta Shirye-shiryen Thymosin (cakuda na peptides) ana samun su ne daga kyallen dabbobi, don haka aikin ya bambanta sosai.Domin ya riga ya ƙunshi furotin dabba, akwai babban damar alamun rashin lafiyan.Hanyar thymus da aka samo daga biochemically daga thymus ɗan adam sabo ne, tare da ƙarancin amfanin ƙasa amma inganci sosai.Yin la'akari da ƙayyadaddun albarkatun ƙasa, farashi mai girma, ƙarancin amfanin ƙasa, da tsarin saye mai rikitarwa., manyan matsalolin samar da kayayyaki, haɓaka haɓaka ba shi da kyakkyawan fata.
2. Haɗin sinadarai A kasuwa ana samun thymusfasin ne a matsayin SPSS, wanda ake samarwa kuma ana tsarkake shi ta hanyoyin da suka dace.Dangane da guduro, an yi amfani da Fmoc don samuwar lokaci mai ƙarfi, kuma an samar da nau'ikan amino acid iri 28 bisa ga thymalfasin bi da bi.N-terminal amino acid an acetylated tare da acetic anhydride, kuma TFA aka yi amfani da matsayin wani muhimmin fatattaka reagent don fatattaka don samun m kayayyakin.HPLC ta raba ɗanyen samfurin don samun sabon samfurin hanyar thymus, wanda aka ƙara tsarkakewa don samun sabuwar hanyar thymus ɗanyen kayan.
Akwai nau'ikan kwayoyin halitta iri uku
1) An haɗa nau'o'in kwayoyin halitta da yawa a cikin rundunar don samun kwayoyin halitta, kuma a ƙarshe an bayyana su a cikin nau'i na haɗakarwa.An ba da rahoton cewa thymethod novel novel multi-string genes an kafa su ta hanyar bazuwar annealing da dabarun PCR kuma an maimaita su cikin Escherichia coli.(2) An sake haɗa nau'in furotin da aka samar a cikin kafofin watsa labaru, kuma kafofin watsa labaru sun canza zuwa mai watsa shiri don gina kwayoyin halitta.Alal misali, bisa ga siginar peptide na siginar da ke cikin plasmid, an gina kalmar plasmid, an canza shi zuwa Pichia pastoris ta hanyar electroexcitation, sa'an nan kuma furotin na fusion ya haifar da methanol, sa'an nan kuma an gina sabuwar hanyar thymus ta hanyar narkewar enzyme da sauran hanyoyi. .
Lokacin aikawa: Satumba-08-2023