Wadannan peptides na antimicrobial an samo asali ne daga tsarin kariya na kwari, dabbobi masu shayarwa, amphibians, da sauransu, kuma sun hada da nau'i hudu:
1. Cecropin ya kasance a asali a cikin ƙwayoyin rigakafi na Cecropiamoth, wanda galibi ana samunsa a cikin wasu kwari, kuma ana samun irin wannan peptides na ƙwayoyin cuta a cikin hanjin alade.Yawanci ana siffanta su da wani yanki mai ƙarfi na alkaline N-terminal wanda ke biye da guntun hydrophobic mai tsayi.
2. Xenopus antimicrobial peptides (magainin) ana samun su daga tsokoki da ciki na kwadi.Hakanan an gano tsarin xenopus antimicrobial peptides yana da ƙarfi, musamman a cikin mahallin hydrophobic.An yi nazarin daidaitawar xenopus antipeptides a cikin yaduddukan lipid ta N-labeled solid-phase NMR.Dangane da canjin sinadarai na resonance na acylamine, helices na xenopus antipeptides sun kasance daidaitattun saman bilayer, kuma suna iya haɗuwa don samar da kejin 13mm tare da tsarin helical na lokaci-lokaci na 30mm.
3. defensin Tsaro peptides aka samu daga mutum polykaryotic neutrophil zomo polymacrophages tare da cikakken nukiliya lobule da hanji Kwayoyin na dabbobi.An fitar da rukuni na peptides na antimicrobial mai kama da peptides na kare dabbobi masu shayarwa daga kwari, wanda ake kira "peptides na kare kwari".Ba kamar peptides na kariya na dabbobi masu shayarwa ba, peptides na kariya na kwari suna aiki ne kawai da ƙwayoyin cuta na Gram.Hatta peptides na kariya na kwari sun ƙunshi ragowar Cys guda shida, amma hanyar disulfide bonding da juna ya bambanta.Yanayin daurin gadar disulfide na intramolecular na peptides na ƙwayoyin cuta da aka samo daga Drosophila melanogast ya yi kama da na peptides na tsaro na shuka.A ƙarƙashin yanayin crystal, ana gabatar da peptides na tsaro azaman dimers.
4.Tachyplesin an samo shi daga kaguwar doki, wanda ake kira doki.Nazarin kanfigareshan ya nuna cewa yana ɗaukar tsarin nadawa B na antiparallel (matsayi 3-8, matsayi na 11-16), wanda a ciki.β-Angle yana haɗa da juna (8-11 matsayi), kuma ana haifar da haɗin disulfide guda biyu tsakanin matsayi na 7 da 12, kuma tsakanin matsayi na 3 da 16.A cikin wannan tsari, amino acid na hydrophobic yana a gefe ɗaya na jirgin, kuma ragowar cationic guda shida suna bayyana akan wutsiya na kwayoyin halitta, don haka tsarin shima biophilic ne.
Ya biyo bayan cewa kusan dukkanin peptides antimicrobial suna da cationic a cikin yanayi, kodayake sun bambanta da tsayi da tsayi;A babban ƙarshen, ko a cikin nau'i na alpha-helical koβ- ninkawa, tsarin bitropic shine fasalin gama gari.
Lokacin aikawa: Afrilu-20-2023