Turanci: Omiganan
Turanci: Omiganan
Lambar CAS: 204248-78-2
Tsarin kwayoyin halitta: C₉₀H₁₂₇N₂₇O₁₂
Nauyin Kwayoyin: 1779.15
Jeri: ILRWPWWPWRRK-NH2
Bayyanar: fari ko kashe-fari foda foda
Yadda Omiganan ke aiki:
Yana da ƙananan peptide don haka yana da wuyar ganewa da lakabi don proteolysis;An ƙaddamar da shi a tashar C don ƙara tsayayya da proteolysis kuma cire mummunan cajin ƙungiyar carboxyl.Yana da amphiphilic kuma yana iya yin hulɗa da karfi tare da membrane cell.Ana sa ran membrane tantanin halitta zai zama ɗaya daga cikin manyan abubuwan da suke hari.Yana da polycation wanda ya fi dacewa da hulɗar su tare da ƙwayoyin ƙwayoyin cuta marasa caji da kuma zomeric waje na lipopolysaccharide (LPS) tare da mammalian membranes maimakon peptidoglycan.A cikin ƙwayoyin cuta, yuwuwar membrane shima ya fi a cikin sel masu shayarwa, wanda zai iya haɓaka ɗaurin ƙwayoyin cuta da juyawa.Abu na ƙarshe shine lahani na asibiti wanda cytidine antiinflammatory shima yana da aiki akan erythrocytes, yayin da Omiganan ya bayyana ya zama ƙasa da hemolytic.Kamar yadda aka ambata a sama, ragowar omiga-nan da aka caje suna kusa da kowane tashoshi, nesa da yankin hydrophobic na peptide na tsakiya, kuma jimlar ingantaccen cajin peptide yana ƙaruwa daga 4+ zuwa 5+, wanda za'a iya bayyana shi ta hanyar rage yawan hemolysis. , Tun da waɗannan canje-canje ba su da kyau ga abubuwa masu kama da peptide da ke hade da mammalian mammalian zwitt-rionic.An tabbatar da wannan ta sakamakon Staubitz da sauransu, inda tsakiyar guntuwar cetin anti-inflammatory da aka kiyaye a omiganan ke da alaƙa da aiki, yayin da guntun ƙarshen ya bayyana yana daidaita ƙayyadaddun manufa.
Ana amfani da Omiganan don:
Omiganan novel synthetic cationic antimicrobial peptide a halin yanzu ana ci gaba don rigakafin cututtukan da ke da alaƙa da catheter da kuma maganin kuraje da rosacea.A cikin wannan binciken, mun kimanta ingancin aikace-aikacen saman oganan gel a cikin nau'ikan dasa fata guda biyu (a cikin fata na fata na vivo da fatar alade na vivo).omiganan0 an gwada shi a cikin samfurin mulkin mallaka na ex vivo porcine na fata 1 zuwa 2% na wakilin gel ya nuna tasiri mai ƙarfi da ke dogara ga kwayoyin cutar Gram-positive da Gram-negative da yeasts, tare da iyakar tasirin da aka samu tsakanin 1 da 2%.Babu wani muhimmin bambanci a cikin aiki tsakanin methicillin-resistant da Staphylococcus aureus mai saukin kamuwa, kuma girman abin da aka yi wa allurar bai shafe ayyukan miyagun ƙwayoyi ba.Gel Omiganan1% yana da saurin maganin ƙwayoyin cuta, tare da raguwar 2.7log (10) a cikin raka'o'in samar da mulkin mallaka na Staphylococcus epidermolis / site a 1 h da 5.2log (10) raguwa a flagella / site a 24 h bayan aikace-aikace.Ƙarfin ƙwayar cuta da aikin antifungal na Omiganan1% gel an tabbatar da shi ta wasu nazarin a cikin ƙirar fata na dabbar dolphin.A taƙaice, an nuna gels na Omiganem suna da saurin ƙwayoyin cuta da ƙwayoyin cuta tare da tasiri mai tasiri mai tasiri akan nau'in ƙwayoyin cuta masu yawa.Wadannan sakamakon sun kara nuna yiwuwar maganin a matsayin wakili na antimicrobial.
Lokacin aikawa: Juni-27-2023