Menene rawar phosphorylation a cikin peptides?

Phosphorylation yana rinjayar duk abubuwan rayuwa na salon salula, kuma sunadaran sunadaran suna shafar duk wani nau'i na ayyukan sadarwa na ciki ta hanyar daidaita hanyoyin sigina da tsarin salula.Duk da haka, aberrant phosphorylation kuma shine sanadin cututtuka da yawa;musamman, mutated protein kinase da phosphatases na iya haifar da cututtuka da yawa, kuma yawancin gubobi na halitta da ƙwayoyin cuta suma suna da tasiri ta hanyar canza yanayin phosphorylation na sunadaran intracellular.

Phosphorylation na serine (Ser), threonine (Thr), da tyrosine (Tyr) tsari ne mai jujjuya furotin.Suna da hannu a cikin daidaita yawan ayyukan salula, kamar siginar mai karɓa, ƙungiyar furotin da rarrabuwa, kunnawa ko hana aikin gina jiki, har ma da rayuwa ta salula.Ana cajin phosphates mara kyau (caji mara kyau biyu a kowace rukunin phosphate).Sabili da haka, ƙari na su yana canza kaddarorin sunadaran, wanda yawanci canji ne na daidaituwa, yana haifar da canji a cikin tsarin furotin.Lokacin da aka cire rukunin phosphate, haɓakar furotin zai dawo zuwa asalinsa.Idan sunadaran halitta guda biyu suna nuna ayyuka daban-daban, phosphorylation na iya aiki azaman canjin kwayoyin halitta don sunadaran don sarrafa ayyukansa.

Yawancin hormones suna daidaita ayyukan takamaiman enzymes ta hanyar haɓaka yanayin phosphorylation na serine (Ser) ko ragowar threonine (Thr), kuma tyrosine (Tyr) phosphorylation na iya haifar da abubuwan haɓaka (kamar insulin).Ƙungiyoyin phosphate na waɗannan amino acid za a iya cire su da sauri.Don haka, Ser, Thr, da Tyr suna aiki azaman masu sauyawa na ƙwayoyin cuta a cikin ka'idodin ayyukan salula kamar haɓakar ƙari.

peptides na roba suna taka muhimmiyar rawa a cikin nazarin abubuwan gina jiki kinase substrates da hulɗa.Duk da haka, akwai wasu abubuwan da ke hanawa ko iyakance daidaitawar fasahar haɗin gwiwar phosphopeptide, kamar rashin iya cimma cikakken aiki da aiki mai ƙarfi mai ƙarfi da kuma rashin haɗin kai mai dacewa tare da daidaitattun dandamali na nazari.

Tsarin dandamali na tushen peptide da fasahar gyare-gyaren phosphorylation ya shawo kan waɗannan iyakoki yayin inganta haɓakar haɓakawa da haɓakawa, kuma dandamali ya dace sosai don nazarin furotin kinase substrates, antigens, ƙwayoyin ɗaure, da masu hanawa.