Glucagon-kamar peptide 1 agonists (GLP-1R) agonists an samo su don rage amfani da barasa a cikin rodents da masu kiba masu fama da matsalar shan barasa (AUD).Koyaya, ƙananan allurai na semaglutide (semaglutide), mai hanawa mai ƙarfi na GLP-1, an nuna don rage amfani da barasa a cikin rodents da masu kiba tare da AUD.Yiwuwar cewa agonist mai ƙarfi mai ƙarfi da kusanci ga GLP-1R) yana rage martanin da ke da alaƙa da barasa a cikin rodents, da kuma hanyoyin da ke cikin jijiyoyin jijiya, ba a san su ba.
Somallutide, maganin da ake amfani da shi a halin yanzu don maganin ciwon sukari na 2 da kiba, na iya zama ingantaccen magani na dogaro da barasa.a wani binciken da aka buga a mujallar eBioMedicine ta kasa da kasa mai taken "Semaglutide Yana Rage Shan Barasa Da Komawar Shaye-shaye a cikin Berayen Namiji da Na Mata," Masana kimiyya daga Jami'ar Gothenburg da sauran cibiyoyi sun gano cewa somallutide na iya rage koma bayan barasa da shan barasa a cikin berayen ta hanyar amfani da barasa. fiye da rabi.
Bukatar somallutide, wanda ake siyar da su a ƙarƙashin sunaye irin su Ozempic (semaglutide), ya karu tun lokacin da aka amince da maganin don maganin kiba, wanda kwanan nan ya sa ya zama mai wahala sosai;Haka kuma an samu rahotannin almara na masu fama da kiba ko ciwon suga suna cewa sha’awar shaye-shaye ya ragu bayan sun fara shan maganin.A zamanin yau, ana kula da mutanen da ke da barasa tare da haɗakar hanyoyin psychosocial da kwayoyi.A halin yanzu akwai magunguna guda huɗu da aka amince dasu.Tunda dogaro da barasa cuta ce da ke da dalilai da yawa da ingancin waɗannan magunguna daban-daban, haɓaka ƙarin hanyoyin warkewa yana da mahimmanci musamman.
Somallutide magani ne na dogon lokaci wanda marasa lafiya ke buƙatar sha sau ɗaya kawai a mako, kuma shine magani na farko da ya fara aiki akan mai karɓar GLP-1 wanda za'a iya ɗauka azaman kwamfutar hannu.A cikin binciken, masu binciken sun yi maganin berayen da ke dogara da barasa tare da somalutide, wanda ya rage yawan barasa na berayen, har ma ya rage yawan shan barasa da ke da alaƙa da komawar barasa, babbar matsala ga masu shan barasa saboda mutane suna komawa baya bayan wani lokaci na kauracewa da kuma cinye barasa da yawa. fiye da yadda suke yi kafin kauracewa.Berayen da aka yi musu magani sun iya rage shan barasa da rabi idan aka kwatanta da berayen da ba a kula da su ba, in ji masu binciken.Wani bincike mai ban sha'awa a cikin binciken shine cewa somallutide ya rage yawan barasa daidai a cikin berayen maza da mata.
Har ila yau, binciken ya ba da rahoton sakamako mai kyau mai ban mamaki, kodayake nazarin asibiti na somallutide har yanzu yana da nisa kafin a iya amfani da shi don magance barasa;A ci gaba, maganin zai iya zama mafi fa'ida ga masu kiba da kuma dogaro da barasa, kuma masu binciken sun ce sakamakon zai iya kaiwa ga mutane, kamar yadda sauran nazarin magungunan barasa ta hanyar amfani da samfuran bincike masu alaƙa sun nuna cewa ɗan adam na iya samun irin wannan tasirin warkewa ko tasiri. kamar beraye.Farfesa Elisabet Jerlhag ta ce, ba shakka, akwai bambance-bambance tsakanin binciken da ake yi a kan dabbobi da mutane, kuma dole ne masu bincike su yi la'akari da wadannan bambance-bambance;A wannan yanayin, duk da haka, binciken da aka yi a baya a cikin mutane ya nuna cewa an gano wani tsohuwar ƙwayar maganin ciwon sukari da ke aiki akan GLP-1 don rage yawan barasa a cikin mutane masu kiba da barasa.
Har ila yau, binciken na yanzu ya yi nazari kan dalilin da ya sa miyagun ƙwayoyi somallutide ya rage yawan barasa na mutum, yana nuna cewa rage ladan kwakwalwar barasa da azabtarwa na iya zama abin taimakawa;A cikin takardar, masu binciken sun gano cewa yana shafar sakamako da tsarin horo na kwakwalwar linzamin kwamfuta.Musamman ma, yana rinjayar yankin tsakiya na tsakiya, wanda shine ɓangare na tsarin limbic.Masu binciken sun yi imanin cewa barasa yana kunna lada da tsarin horo na kwakwalwa, wanda ke haifar da sakin dopamine, wanda ake iya gani a cikin mutane da dabbobi, kuma wannan tsari yana toshewa bayan an yi wa berayen magani, wanda zai iya haifar da raguwar ladan barasa da kuma haifar da shi. azabtarwa a cikin jiki, masu bincike sunyi imani.
A ƙarshe, sakamakon wannan binciken ya nuna cewa somallutide na iya rage halayen shan barasa, wanda za a iya shiga tsakani ta hanyar rage sakamakon sakamako / azabtar da barasa da kuma tsarin ƙwayar ƙwayar cuta."Kamar yadda somallutide kuma ya rage nauyin jiki a cikin jinsi biyu na berayen masu shan barasa, nazarin asibiti na gaba zai bincika ingancin somallutide wajen rage yawan shan barasa da nauyin jiki a cikin marasa lafiya masu kiba da matsalar shan barasa."
Lokacin aikawa: Nuwamba-07-2023