PYY peptides antifungal ne kuma suna kula da lafiyar ƙwayoyin cuta na hanji

Lokacin da ƙungiyar ta gano wannan nau'i na C. albicans ta amfani da PYY, bayanan sun nuna cewa PYY ya dakatar da haɓakar waɗannan ƙwayoyin cuta yadda ya kamata, yana kashe ƙarin nau'in fungal na C. albicans da kuma riƙe nau'in yisti na simbiotic na C. albicans.

Ƙungiyar Eugene Chang a Jami'ar Chicago ta buga takarda a cikin mujallar Kimiyya mai suna: Peptide YY: A Paneth cell antimicrobial peptide da ke kula da Candida gut commensalism.

YY peptide (PYY) Hormone na hanji ne wanda aka bayyana kuma ya ɓoye ta ƙwayoyin enteroendocrine (ECC) don sarrafa ci ta hanyar samar da gamsuwa.Binciken da aka yi kwanan nan ya gano cewa PanethCell wanda ba na hanji ba yana bayyana wani nau'i na PYY, wanda zai iya aiki a matsayin peptide na antimicrobial (AMP), wanda kuma yana taka muhimmiyar rawa wajen kiyaye microbiota na hanji lafiya da kuma hana Candida albicans daga zama mai haɗari pathogenic. yanayin.

An san kadan game da tsarin waɗannan ƙwayoyin cuta ta hanjin mu microbiome.Mun dai san cewa bakteriya suna can, amma ba mu san abin da ke da amfani ga lafiyar mu ba.Binciken da aka yi kwanan nan ya nuna cewa peptides na YY suna da mahimmanci a haƙiƙa don kiyaye symbiosis na ƙwayoyin cuta na hanji.

Da farko, ƙungiyar ba ta shirye don nazarin ƙwayoyin cuta a cikin microbiome na gut ba.Lokacin da Joseph Pierre, marubucin farko na takarda, yana nazarin ƙwayoyin endocrin na hanji na PYY masu samar da beraye, Dokta Joseph Pierre ya lura cewa PYY kuma yana da Panethcells, waɗanda ke da mahimmancin tsarin garkuwar jiki a cikin hanjin dabbobi masu shayarwa da kuma hana yaduwar ƙwayoyin cuta masu haɗari. ta hanyar metabolizing da yawa mahadi na bacterosuppressive.Wannan bai yi kama da ma'ana ba saboda a baya an yi tunanin PYY hormone ne kawai na ci.Lokacin da tawagar ta gano kwayoyin cuta iri-iri, an gano cewa PYY ba ta da kyau wajen kashe su.

PYY peptides antifungal ne kuma suna kula da lafiyar ƙwayoyin cuta na hanji

Duk da haka, lokacin da suka nemi wasu nau'ikan peptides masu kama da tsari, sun sami PYY-kamar peptide -Magainin2, peptide na antimicrobial da ke cikin fata Xenopus wanda ke ba da kariya daga cututtukan ƙwayoyin cuta da fungal.Don haka, tawagar ta tashi don gwada abubuwan da ake amfani da su na maganin fungal na PYY.A gaskiya ma, PYY ba kawai maganin rigakafi ba ne mai tasiri sosai amma kuma takamaiman maganin rigakafi ne.

PYY mai inganci, wanda ba a canza shi ba yana da amino acid 36 (PYY1-36) kuma shine peptide mai ƙarfi na antifungal lokacin da ƙwayoyin Paneth suka daidaita shi cikin hanji.Amma lokacin da kwayoyin halittar endocrin suka samar da PYY, sai a cire shi daga amino acid guda biyu (PYY3-36) kuma a canza shi zuwa wani hormone na hanji wanda zai iya tafiya ta cikin jini don haifar da jin dadi wanda ke gaya wa kwakwalwa cewa ba ku da yunwa.

Candida albicans (C.albicans), kuma aka sani da Candida albicans, kwayoyin cuta ne da ke tsiro a baki, fata da hanji.Yana da daraja a cikin jiki a cikin ainihin siffar yisti, amma a cikin matsakaicin yanayi yana canzawa zuwa abin da ake kira siffar fungal, wanda ke ba shi damar girma da yawa, yana haifar da bugun jini, cututtuka na baki da makogwaro, cututtuka na farji, ko mafi tsanani. cututtuka na tsarin.

Lokacin da ƙungiyar ta gano wannan nau'i na C. albicans ta amfani da PYY, bayanan sun nuna cewa PYY ya dakatar da haɓakar waɗannan ƙwayoyin cuta yadda ya kamata, yana kashe ƙarin nau'in fungal na C. albicans da kuma riƙe nau'in yisti na simbiotic na C. albicans.