Bayani da kuma amfani da cerulein

Dubawa

Caerulein, wanda kuma aka sani da cerulein, wani tsantsa fata ne na kwaɗin HYlacaerulea na Australiya wanda ya ƙunshi amino acid 10.Yana da kwayoyin decapeptide da aka ba da ita ta hanyar trifluoroacetate wanda ke aiki azaman analog na cholecystokinin akan sel vesicular na pancreatic kuma yana iya haifar da ɓoyewar adadin enzymes masu narkewa da ruwan 'ya'yan itace pancreatic, wanda ke haifar da m edematous pancreatitis.Za a iya amfani da Cerutin don nazarin Nf-κb up-regulation sunadaran irin su intercellular adhesion molecule-1 (ICAM-1) abubuwan da ke da alaka da kumburi irin su NADPH oxidase da Janus kinase transduction siginar.An yi amfani da shi cikin nasara don kafa samfuran m pancreatitis a cikin berayen, mice, karnuka, da hamsters na Syria (AP).Ruwan da ke ciki ya fi dacewa da allurar ta ciki, dermal, ko intraperitoneal.Ana amfani da shi sosai a cikin gwaje-gwajen asibiti na m edematous pancreatitis, kuma ana amfani da gwaje-gwajen in vitro ga samfuran sel.Bugu da ƙari, ana amfani da shi don gwajin aikin gallbladder.

Bayani da kuma amfani da cerulein

Cikakken bayani

Bayyanar: farin foda

Lambar CAS: 17650-98-5

Lambar Gutuo: GT-F055

Jeri: pGlu-Gln-Asp-Tyr(SO3H) -Thr-Gly-Trp-Met-Asp-Phe-NH2

Tsarin kwayoyin halitta: C58H73N13O21S2

Nauyin Kwayoyin: 1352.4

Solubility: Narkar da a 50mM ammonium hydroxide a taro na 1.0mg/ml

Aikace-aikace

1. An yi amfani da shi sosai a cikin ƙirar ƙira na m edematous pancreatitis a cikin gwaji na asibiti.

2. Aikace-aikace zuwa samfurin salula a cikin vitro.

3. Ana amfani dashi don gwajin aikin gallbladder.

Don haɓaka samfurin don nazarin m pancreatitis don nazarin ilmin halitta na cerulein (AP), halayen pathophysiological da bayyanar cututtuka na kwayoyin cuta a cikin m pancreatitis.Baya ga bincikar canje-canje na huhu na cutar AP, yana iya nuna yadda ya kamata ya nuna ma'amalar endocrin visceral kamar matakin metabolin da CCK.Hakanan za'a iya amfani dashi don tantance gyarawa da dawo da kyallen jikin da suka ji rauni bayan ƙare abubuwa masu haɗari.

5. Yin amfani da Caerulein cerulein (cerulein) da LPS don kafa samfurori na pancreatic na iya haifar da tasirin haɗin gwiwa, tsohon zai iya ƙarfafa enzymes na pancreatic don halakar da pancreas, kuma ya ci gaba da kunna ƙwayoyin ƙwayoyin cuta don saki abubuwan da ke haifar da kumburi.Daga baya, LPS yana rushe martani na yau da kullun na masu shiga tsakani masu kumburi, don haka haɓaka ƙwayar cuta na gida a matsayin babban yanayin kumburin tsari.

6. Ana iya amfani da Cerulein don hana ciwon gallbladder, colic na koda, da kuma ciwon claudication na tsaka-tsaki.Gabaɗaya ana la'akari da shi azaman antagonist kephalin endogenous.