Binciken dabarun hada-hadar peptide

Fasahar haɓaka kamar Peptide

Bincike da haɓaka magungunan peptide suna girma cikin sauri a cikin magani.Duk da haka, ci gaban magungunan peptide yana iyakance ta halaye na kansu.Alal misali, saboda ƙwarewa na musamman ga enzymatic hydrolysis, kwanciyar hankali yana raguwa, kuma sauye-sauyen sauye-sauye na steric yana haifar da ƙananan ƙayyadaddun niyya, ƙananan hydrophobicity, da rashin tsarin sufuri na musamman.Domin shawo kan wadannan peptides, da shawarar da yawa mafita da kuma nasarar aikace-aikace na daya irin peptide ne daya daga cikinsu.

Nau'in peptide (Sunan Ingilishi: Peptoid) ko Poly - N - maimakon glycine (Sunan Ingilishi: Poly real - N - maye gurbin glycine), ƙananan peptide mahadi ne na peptide a cikin babban sarkar.Sarkar gefen alpha carbon yana canja wurin babban sarkar nitrogen maimakon sarkar gefe.A cikin asalin polypeptide, rukunin R na sarkar gefen amino acid suna wakiltar amino acid daban-daban guda 20, amma ƙungiyar R tana da ƙarin zaɓuɓɓuka a cikin peptoid.A cikin peptide, peptide a kan babban sarkar amino acid a cikin alpha carbon nitrogen maimakon canja wurin sarkar gefe zuwa babban sarkar.Ya kamata a ambata cewa peptides gabaɗaya ba sa samar da sifofin da aka ba da umarni iri ɗaya kamar tsarin na biyu a cikin peptides da sunadarai saboda ƙarancin hydrogen akan nitrogen na kashin baya.Manufar farko ta Peptide ita ce haɓaka barga da haɓaka peptide na ƙananan ƙwayoyin ƙwayoyin cuta.

Binciken dabarun hada-hadar peptide

An gabatar da hanyar haɗin peptide

Shahararriyar hanyar hada nau'in peptide mai kama da ita ita ce hanyar haɗin kai guda ɗaya da RonZuckermann ya ƙirƙira, kowanne daga cikinsu ya kasu kashi biyu: acylation da ƙaura.A cikin acylation, mataki na farko shine kunna haloacetic acid don amsawa tare da amines da suka rage a ƙarshen mataki na baya, mafi yawan diisopropyl carbonized diimine.An kunna bromoaceticacid ta diisopropylcarbodiimide."A cikin halayen maye (halayen maye gurbin bimolecular nucleophilic), amine, yawanci na farko, yana kai hari ga madadin halogen don samar da glycine da aka maye gurbinsa."Hanyar haɗin gwiwar ƙasa tana amfani da amines na farko a shirye don samar da peptides, wanda ke ba da damar haɗin sinadarai na peptides.

M tsawo a cikin aji peptides kira yana da arha gwaninta, zai iya ba ku da iri-iri na irin peptide kira sabis.

Binciken dabarun hada-hadar peptide

Amfanin irin wannan peptide

Mafi kwanciyar hankali: peptoids sun fi kwanciyar hankali a cikin vivo fiye da peptides.

Ƙarin zaɓi: Peptoids sun dace sosai don haɗakar binciken gano magunguna saboda ana iya samun babban nau'in tubalan ginin polypeptide daban-daban ta hanyar gyara rukunin amino ɗin kashin baya.

Ingantacciyar inganci: Yawancin tsarin peptoid na iya sanya peptoid ya zama kyakkyawan zaɓi don hanyoyin bincika don gano takamaiman tsarin da ke ɗaure da sunadaran.

Ƙarin yuwuwar kasuwa: halaye na nau'in peptide bari ya zama nau'in haɓakar ƙwayoyi yana da babbar dama.